Reactome | CUL1, SKP1, FBXL5 bind

Schema > Reaction > Entries

CUL1, SKP1, FBXL5 bind Show undefined attributes

authored	[InstanceEdit:5691161] Jassal, Bijay, 2015-05-05
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5691161] Jassal, Bijay, 2015-05-05
dbId	5691167
displayName	CUL1, SKP1, FBXL5 bind
edited	[InstanceEdit:5691161] Jassal, Bijay, 2015-05-05
eventOf	[Pathway:R-HSA-917937] Iron uptake and transport - Homo sapiens
followingEvent	[Reaction:R-HSA-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-174230] CUL1 [cytosol] [EntityWithAccessionedSequence:R-HSA-391295] FBXL5 [cytosol] [EntityWithAccessionedSequence:R-HSA-174150] SKP1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5691156] An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis [LiteratureReference:5691109] Control of iron homeostasis by an iron-regulated ubiquitin ligase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	CUL1, SKP1, FBXL5 bind
orthologousEvent	[Reaction:R-SCE-5691167] CUL1, SKP1, FBXL5 bind - Saccharomyces cerevisiae [Reaction:R-DDI-5691167] CUL1, SKP1, FBXL5 bind - Dictyostelium discoideum [Reaction:R-DRE-5691167] CUL1, SKP1, FBXL5 bind - Danio rerio [Reaction:R-BTA-5691167] CUL1, SKP1, FBXL5 bind - Bos taurus [Reaction:R-CFA-5691167] CUL1, SKP1, FBXL5 bind - Canis familiaris [Reaction:R-RNO-5691167] CUL1, SKP1, FBXL5 bind - Rattus norvegicus [Reaction:R-MMU-5691167] CUL1, SKP1, FBXL5 bind - Mus musculus
output	[Complex:R-HSA-5691178] SKP1:CUL1:FBXL5 [cytosol]
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8954302] D'Eustachio, Peter, 2017-01-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5691167
summation	[Summation:8954300] Cellular iron homeostasis is maintained by the coordinate po...

Referrals

(hasEvent)	[Pathway:R-HSA-917937] Iron uptake and transport
(precedingEvent)	[Reaction:R-HSA-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)