Reactome | NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)

Schema > Reaction > Entries

NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10619192
displayName	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)
eventOf	[Pathway:R-DRE-917937] Iron uptake and transport - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5691108] SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 - Danio rerio
inferredFrom	[Reaction:R-HSA-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) - Homo sapiens
input	[DefinedSet:R-DRE-416969-3] Homologues of NEDD8 [cytosol] [Complex:R-DRE-5691178] SKP1:CUL1:FBXL5 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)
output	[Complex:R-DRE-5691141] SKP1:FBXL5:CUL1:NEDD8 [cytosol]
precedingEvent	[Reaction:R-DRE-5691167] CUL1, SKP1, FBXL5 bind - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5691176
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-917937] Iron uptake and transport
(precedingEvent)	[Reaction:R-DRE-5691108] SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2
(inferredTo)	[Reaction:R-HSA-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)

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