Reactome | TFIIH binds GG-NER site to form a verification complex

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TFIIH binds GG-NER site to form a verification complex Show undefined attributes

authored	[InstanceEdit:73956] Joshi-Tope, G, 2003-07-14 15:01:00 [InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:5691005] Orlic-Milacic, Marija, 2015-05-04
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5690999] Orlic-Milacic, Marija, 2015-05-04
dbId	5691000
displayName	TFIIH binds GG-NER site to form a verification complex
edited	[InstanceEdit:5691005] Orlic-Milacic, Marija, 2015-05-04
eventOf	[Pathway:R-HSA-5696395] Formation of Incision Complex in GG-NER - Homo sapiens
followingEvent	[Reaction:R-HSA-5689861] Recruitment of XPA and release of CAK - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17148] nucleotide-excision repair, preincision complex assembly
input	[Complex:R-HSA-109634] TFIIH [nucleoplasm] [Complex:R-HSA-5696681] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:110564] Sequential assembly of the nucleotide excision repair factors in vivo. [LiteratureReference:110738] Protein complexes in nucleotide excision repair. [LiteratureReference:5688436] Molecular structure of human TFIIH [LiteratureReference:5689245] Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH [LiteratureReference:5689254] p52 Mediates XPB function within the transcription/repair factor TFIIH [LiteratureReference:5689251] Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH [LiteratureReference:5688434] Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH [LiteratureReference:5688454] A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A [LiteratureReference:5689261] The comings and goings of nucleotide excision repair factors on damaged DNA [LiteratureReference:5689262] The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA [LiteratureReference:5689269] Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	TFIIH binds GG-NER site to form a verification complex
orthologousEvent	[Reaction:R-MMU-5691000] TFIIH binds GG-NER site to form a verification complex - Mus musculus [Reaction:R-PFA-5691000] TFIIH binds GG-NER site to form a verification complex - Plasmodium falciparum [Reaction:R-DDI-5691000] TFIIH binds GG-NER site to form a verification complex - Dictyostelium discoideum [Reaction:R-CEL-5691000] TFIIH binds GG-NER site to form a verification complex - Caenorhabditis elegans [Reaction:R-DME-5691000] TFIIH binds GG-NER site to form a verification complex - Drosophila melanogaster [Reaction:R-GGA-5691000] TFIIH binds GG-NER site to form a verification complex - Gallus gallus [Reaction:R-XTR-5691000] TFIIH binds GG-NER site to form a verification complex - Xenopus tropicalis [Reaction:R-DRE-5691000] TFIIH binds GG-NER site to form a verification complex - Danio rerio [Reaction:R-SSC-5691000] TFIIH binds GG-NER site to form a verification complex - Sus scrofa [Reaction:R-BTA-5691000] TFIIH binds GG-NER site to form a verification complex - Bos taurus [Reaction:R-CFA-5691000] TFIIH binds GG-NER site to form a verification complex - Canis familiaris [Reaction:R-RNO-5691000] TFIIH binds GG-NER site to form a verification complex - Rattus norvegicus
output	[Complex:R-HSA-5689862] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5696655] PARP1 or PARP2 PARylates DDB2 and autoPARylates - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
revised	[InstanceEdit:5691005] Orlic-Milacic, Marija, 2015-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5691000
summation	[Summation:5690984] Transcription factor II H (TFIIH) complex is recruited to DN...

Referrals

(hasEvent)	[Pathway:R-HSA-5696395] Formation of Incision Complex in GG-NER
(precedingEvent)	[Reaction:R-HSA-5689861] Recruitment of XPA and release of CAK

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