Reactome | TFIIH [nucleoplasm]

Schema > Complex > Entries

TFIIH [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:109879] 3'-5' DNA helicase activity of TFIIH [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-167127] HIV-1 transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] - Homo sapiens [Complex:R-HSA-167102] HIV-1 transcription complex containing extruded transcript to +30 [nucleoplasm] - Homo sapiens [Complex:R-HSA-73716] RNA Polymerase I Transcription Initiation complex [nucleoplasm] - Homo sapiens [Complex:R-HSA-73717] RNA Polymerase I promoter escape complex [nucleoplasm] - Homo sapiens [Complex:R-HSA-167124] HIV-1 transcription complex containing 4 nucleotide long transcript [nucleoplasm] - Homo sapiens [Complex:R-HSA-167472] HIV-1 Promoter Escape Complex [nucleoplasm] - Homo sapiens [Complex:R-HSA-75859] Pol II Promoter Escape Complex [nucleoplasm] - Homo sapiens [Complex:R-HSA-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] - Homo sapiens [Complex:R-HSA-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-109639] Formation of the closed pre-initiation complex - Homo sapiens [Reaction:R-HSA-5691000] TFIIH binds GG-NER site to form a verification complex - Homo sapiens [Reaction:R-HSA-167072] Hypophosphorylation of RNA Pol II CTD by FCP1P protein - Homo sapiens [Reaction:R-HSA-73758] Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter - Homo sapiens [Reaction:R-HSA-112383] Hypophosphorylation of RNA Pol II CTD by FCP1P protein - Homo sapiens [BlackBoxEvent:R-HSA-6781818] RNA Pol II initiates transcription from damaged DNA template - Homo sapiens [Reaction:R-HSA-167196] Recruitment of elongation factors to form HIV-1 elongation complex - Homo sapiens [Reaction:R-HSA-112379] Recruitment of elongation factors to form elongation complex - Homo sapiens [Reaction:R-HSA-167077] Recruitment of elongation factors to form HIV-1 elongation complex - Homo sapiens
created	[InstanceEdit:109625] Joshi-Tope, G, 2004-01-19 02:18:00
crossReference	[DatabaseIdentifier:11891918] ComplexPortal:CPX-2395
dbId	109634
displayName	TFIIH [nucleoplasm]
hasComponent	[Complex:R-HSA-69221] CAK [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-67443] ERCC2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-67439] ERCC3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-65912] GTF2H1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-65914] GTF2H2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-65916] GTF2H3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-65918] GTF2H4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5688446] GTF2H5 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-109634] TFIIH [nucleoplasm] - Mus musculus [Complex:R-RNO-109634] TFIIH [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-109634] TFIIH [nucleoplasm] - Canis familiaris [Complex:R-BTA-109634] TFIIH [nucleoplasm] - Bos taurus [Complex:R-SSC-109634] TFIIH [nucleoplasm] - Sus scrofa [Complex:R-DRE-109634] TFIIH [nucleoplasm] - Danio rerio [Complex:R-XTR-109634] TFIIH [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-109634] TFIIH [nucleoplasm] - Gallus gallus [Complex:R-DME-109634] TFIIH [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-109634] TFIIH [nucleoplasm] - Caenorhabditis elegans [Complex:R-DDI-109634] TFIIH [nucleoplasm] - Dictyostelium discoideum [Complex:R-SPO-109634] TFIIH [nucleoplasm] - Schizosaccharomyces pombe [Complex:R-SCE-109634] TFIIH [nucleoplasm] - Saccharomyces cerevisiae [Complex:R-PFA-109634] TFIIH [nucleoplasm] - Plasmodium falciparum
literatureReference	[LiteratureReference:5688436] Molecular structure of human TFIIH [LiteratureReference:5688434] Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH [LiteratureReference:5688454] A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A
modified	[InstanceEdit:11891188] Wright, Adam, 2024-03-11
name	TFIIH
producedByEvent	[Reaction:R-HSA-167072] Hypophosphorylation of RNA Pol II CTD by FCP1P protein - Homo sapiens [Reaction:R-HSA-112383] Hypophosphorylation of RNA Pol II CTD by FCP1P protein - Homo sapiens [Reaction:R-HSA-167181] Addition of nucleotides leads to HIV-1 transcript elongation - Homo sapiens [Reaction:R-HSA-112385] Addition of nucleotides leads to transcript elongation - Homo sapiens [Reaction:R-HSA-167468] Abortive HIV-1 Initiation After Second Transition - Homo sapiens [BlackBoxEvent:R-HSA-6782234] Recovery of RNA synthesis after TC-NER - Homo sapiens [Reaction:R-HSA-75891] Abortive Initiation After Second Transition - Homo sapiens [Reaction:R-HSA-77090] Methylation of GMP-cap by RNA Methyltransferase - Homo sapiens [Reaction:R-HSA-167474] Abortive HIV-1 Initiation Before Second Transition - Homo sapiens [Reaction:R-HSA-73946] Abortive initiation after formation of the first phosphodiester bond - Homo sapiens [Reaction:R-HSA-167477] Abortive HIV-1 initiation after formation of the first phosphodiester bond - Homo sapiens [Reaction:R-HSA-75856] Abortive Initiation Before Second Transition - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-109634

Referrals

(hasComponent)	[Complex:R-HSA-73716] RNA Polymerase I Transcription Initiation complex [nucleoplasm] [Complex:R-HSA-73717] RNA Polymerase I promoter escape complex [nucleoplasm] [Complex:R-HSA-167102] HIV-1 transcription complex containing extruded transcript to +30 [nucleoplasm] [Complex:R-HSA-167127] HIV-1 transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] [Complex:R-HSA-167107] RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] [Complex:R-HSA-167139] CE:Pol II CTD:Spt5 complex [nucleoplasm] [Complex:R-HSA-167123] RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm] [Complex:R-HSA-75890] pol II transcription complex containing 4-9 nucleotide long transcript [nucleoplasm] [Complex:R-HSA-167471] HIV-1 transcription complex containing 4-9 nucleotide long transcript [nucleoplasm] [Complex:R-HSA-167120] HIV-1 transcription complex containing transcript to +30 [nucleoplasm] [Complex:R-HSA-167132] HIV-1 transcription complex containing 11 nucleotide long transcript [nucleoplasm] [Complex:R-HSA-167100] HIV-1 transcription complex containing 9 nucleotide long transcript [nucleoplasm] [Complex:R-HSA-75859] Pol II Promoter Escape Complex [nucleoplasm] [Complex:R-HSA-167124] HIV-1 transcription complex containing 4 nucleotide long transcript [nucleoplasm] [Complex:R-HSA-167472] HIV-1 Promoter Escape Complex [nucleoplasm] [Complex:R-HSA-167125] HIV-1 closed pre-initiation complex [nucleoplasm] [Complex:R-HSA-167137] HIV-1 open pre-initiation complex [nucleoplasm] [Complex:R-HSA-167106] HIV-1 initiation complex with phosphodiester-PPi intermediate [nucleoplasm] [Complex:R-HSA-167101] HIV-1 transcription complex [nucleoplasm] [Complex:R-HSA-167119] HIV-1 transcription complex containing 3 nucleotide long transcript [nucleoplasm] [Complex:R-HSA-167185] HIV-1 elongation complex containing Tat [nucleoplasm] [Complex:R-HSA-112433] Elongation complex [nucleoplasm] [Complex:R-HSA-167082] HIV-1 elongation complex [nucleoplasm] [Complex:R-HSA-109635] pol II closed pre-initiation complex [nucleoplasm] [Complex:R-HSA-109876] pol II open pre-initiation complex [nucleoplasm] [Complex:R-HSA-83591] RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] [Complex:R-HSA-83601] Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] [Complex:R-HSA-109878] pol II transcription complex [nucleoplasm] [Complex:R-HSA-75878] pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] [Complex:R-HSA-75881] pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] [Complex:R-HSA-75882] pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] [Complex:R-HSA-75902] pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] [Complex:R-HSA-111261] Pol II transcription complex containing transcript to +30 [nucleoplasm] [Complex:R-HSA-157171] Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] [Complex:R-HSA-157174] Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] [Complex:R-HSA-77053] RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] [Complex:R-HSA-6797611] Elongation Complex at DNA Repair Genes [nucleoplasm] [Complex:R-HSA-6797607] CDK12-Phosphorylated Elongation Complex [nucleoplasm] [Complex:R-HSA-6781990] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] [Complex:R-HSA-9684119] Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] [Complex:R-HSA-6781861] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] [Complex:R-HSA-6781822] Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] [Complex:R-HSA-6781821] Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] [Complex:R-HSA-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] [Complex:R-HSA-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-HSA-6782116] Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] [Complex:R-HSA-6782222] TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-HSA-6782220] TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-HSA-6782230] TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] [Complex:R-HSA-5689862] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] [Complex:R-HSA-77061] CE:Pol II CTD:Spt5 complex [nucleoplasm] [Complex:R-HSA-77056] RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm]
(input)	[Reaction:R-HSA-73758] Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter [Reaction:R-HSA-167196] Recruitment of elongation factors to form HIV-1 elongation complex [Reaction:R-HSA-112379] Recruitment of elongation factors to form elongation complex [Reaction:R-HSA-112383] Hypophosphorylation of RNA Pol II CTD by FCP1P protein [Reaction:R-HSA-167072] Hypophosphorylation of RNA Pol II CTD by FCP1P protein [Reaction:R-HSA-167077] Recruitment of elongation factors to form HIV-1 elongation complex [Reaction:R-HSA-109639] Formation of the closed pre-initiation complex [BlackBoxEvent:R-HSA-6781818] RNA Pol II initiates transcription from damaged DNA template [Reaction:R-HSA-5691000] TFIIH binds GG-NER site to form a verification complex
(output)	[Reaction:R-HSA-73946] Abortive initiation after formation of the first phosphodiester bond [Reaction:R-HSA-167477] Abortive HIV-1 initiation after formation of the first phosphodiester bond [Reaction:R-HSA-75891] Abortive Initiation After Second Transition [Reaction:R-HSA-167468] Abortive HIV-1 Initiation After Second Transition [Reaction:R-HSA-75856] Abortive Initiation Before Second Transition [Reaction:R-HSA-167474] Abortive HIV-1 Initiation Before Second Transition [Reaction:R-HSA-167181] Addition of nucleotides leads to HIV-1 transcript elongation [Reaction:R-HSA-112385] Addition of nucleotides leads to transcript elongation [Reaction:R-HSA-112383] Hypophosphorylation of RNA Pol II CTD by FCP1P protein [Reaction:R-HSA-167072] Hypophosphorylation of RNA Pol II CTD by FCP1P protein [BlackBoxEvent:R-HSA-6782234] Recovery of RNA synthesis after TC-NER [Reaction:R-HSA-77090] Methylation of GMP-cap by RNA Methyltransferase
(physicalEntity)	[CatalystActivity:109879] 3'-5' DNA helicase activity of TFIIH [nucleoplasm]

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