Reactome | PARP1 or PARP2 PARylates DDB2 and autoPARylates

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PARP1 or PARP2 PARylates DDB2 and autoPARylates Show undefined attributes

authored	[InstanceEdit:5691005] Orlic-Milacic, Marija, 2015-05-04
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5696651] Orlic-Milacic, Marija, 2015-05-29
dbId	5696655
displayName	PARP1 or PARP2 PARylates DDB2 and autoPARylates
edited	[InstanceEdit:5691005] Orlic-Milacic, Marija, 2015-05-04
eventOf	[Pathway:R-HSA-5696394] DNA Damage Recognition in GG-NER - Homo sapiens
followingEvent	[Reaction:R-HSA-5691000] TFIIH binds GG-NER site to form a verification complex - Homo sapiens
input	[SimpleEntity:R-ALL-427523] NAD+ [nucleoplasm] [Complex:R-HSA-5696660] Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5696656] PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1 [LiteratureReference:5696650] Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	PARP1 or PARP2 PARylates DDB2 and autoPARylates
orthologousEvent	[Reaction:R-PFA-5696655] PARP1 or PARP2 PARylates DDB2 and autoPARylates - Plasmodium falciparum [Reaction:R-DDI-5696655] PARP1 or PARP2 PARylates DDB2 and autoPARylates - Dictyostelium discoideum [Reaction:R-CEL-5696655] PARP1 or PARP2 PARylates DDB2 and autoPARylates - Caenorhabditis elegans [Reaction:R-DME-5696655] PARP1 or PARP2 PARylates DDB2 and autoPARylates - Drosophila melanogaster [Reaction:R-GGA-5696655] PARP1 or PARP2 PARylates DDB2 and autoPARylates - Gallus gallus [Reaction:R-XTR-5696655] PARP1 or PARP2 PARylates DDB2 and autoPARylates - Xenopus tropicalis [Reaction:R-DRE-5696655] PARP1 or PARP2 PARylates DDB2 and autoPARylates - Danio rerio [Reaction:R-SSC-5696655] PARP1 or PARP2 PARylates DDB2 and autoPARylates - Sus scrofa [Reaction:R-BTA-5696655] PARP1 or PARP2 PARylates DDB2 and autoPARylates - Bos taurus [Reaction:R-CFA-5696655] PARP1 or PARP2 PARylates DDB2 and autoPARylates - Canis familiaris [Reaction:R-RNO-5696655] PARP1 or PARP2 PARylates DDB2 and autoPARylates - Rattus norvegicus [Reaction:R-MMU-5696655] PARP1 or PARP2 PARylates DDB2 and autoPARylates - Mus musculus
output	[SimpleEntity:R-ALL-427497] NAM [nucleoplasm] [Complex:R-HSA-5696681] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5696664] PARP1 or PARP2 binds DDB2 at GG-NER site - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5696655
summation	[Summation:5696666] PARP1 and/or PARP2 homo- or heterodimers recruited to global...

Referrals

(hasEvent)	[Pathway:R-HSA-5696394] DNA Damage Recognition in GG-NER
(precedingEvent)	[Reaction:R-HSA-5691000] TFIIH binds GG-NER site to form a verification complex