Reactome | USP21 is not required for normal development (Pannu et al. 2...

Schema > Summation > Entries

created	[InstanceEdit:5690100] Jupe, Steve, 2015-04-27
dbId	5690092
displayName	USP21 is not required for normal development (Pannu et al. 2...
literatureReference	[LiteratureReference:5690174] Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation [LiteratureReference:5690135] Deubiquitination and stabilization of IL-33 by USP21 [LiteratureReference:5357906] Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1 [LiteratureReference:5690205] USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase
modified	[InstanceEdit:6783058] Jupe, Steve, 2015-06-10
schemaClass	Summation
text	USP21 is not required for normal development (Pannu et al. 2015) but is essential in innate and adaptive immune responses (Tao et al. 2014). It negatively regulates NFkB signaling by deubiquitinating Receptor-interacting protein 1 (RIPK1) (Xu et al. 2010) and DDX58 (RIG-I), thereby down-regulating antiviral responses independently of the A20 ubiquitin-editing complex (Fan et al. 2014).

(summation)

Cite Us!