USP21 deubiquitinates RIPK1,DDX58

Stable Identifier
R-HSA-5690159
Type
Reaction [transition]
Species
Homo sapiens
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USP21 is not required for normal development (Pannu et al. 2015) but is essential in innate and adaptive immune responses (Tao et al. 2014). It negatively regulates NFkB signaling by deubiquitinating Receptor-interacting protein 1 (RIPK1) (Xu et al. 2010) and DDX58 (RIG-I), thereby down-regulating antiviral responses independently of the A20 ubiquitin-editing complex (Fan et al. 2014).

Literature References
PubMed ID Title Journal Year
19910467 Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1

Xu, G, Tan, X, Wang, H, Sun, W, Shi, Y, Burlingame, S, Gu, X, Cao, G, Zhang, T, Qin, J, Yang, J

J. Biol. Chem. 2010
24493797 USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

Fan, Y, Mao, R, Yu, Y, Liu, S, Shi, Z, Cheng, J, Zhang, H, An, L, Zhao, Y, Xu, X, Chen, Z, Kogiso, M, Zhang, D, Zhang, H, Zhang, P, Jung, JU, Li, X, Xu, G, Yang, J

J. Exp. Med. 2014
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Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP21:PolyUb-RIPK1, PolyUb-DDX58 [cytosol]
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