XPA binds the DNA damage site through interaction with the TFIIH complex subunit GTF2H5 (TTDA) (Ziani et al. 2014), and also interacts with the DDB2 subunit of the UV-DDB complex (Wakasugi et al. 2001, Wakasugi et al. 2009, Takedachi et al. 2010). PARylated PARP1 (or possibly PARP2) (King et al. 2012) facilitates XPA association with chromatin. Binding of XPA is accompanied by the release of the CAK subcomplex from the TFIIH complex (Coin et al. 2008).
Wakasugi, M, Shimizu, M, Morioka, H, Linn, S, Nikaido, O, Matsunaga, T
King, BS, Cooper, KL, Liu, KJ, Hudson, LG
Wakasugi, M, Kasashima, H, Fukase, Y, Imura, M, Imai, R, Yamada, S, Cleaver, JE, Matsunaga, T
Takedachi, A, Saijo, M, Tanaka, K
Ziani, S, Nagy, Z, Alekseev, S, Soutoglou, E, Egly, JM, Coin, F
Coin, F, Oksenych, V, Mocquet, V, Groh, S, Blattner, C, Egly, JM
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