Reactome | POLL or POLM extends aligned DNA DSB ends to fill gaps

Schema > Reaction > Entries

POLL or POLM extends aligned DNA DSB ends to fill gaps Show undefined attributes

catalystActivity	[CatalystActivity:11028068] DNA-directed DNA polymerase activity of p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11028070
displayName	POLL or POLM extends aligned DNA DSB ends to fill gaps
eventOf	[Pathway:R-DDI-5693571] Nonhomologous End-Joining (NHEJ) - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5687360] POLL or POLM extends aligned DNA DSB ends to fill gaps - Homo sapiens
input	[SimpleEntity:R-ALL-30555] dNTP [nucleoplasm] [Complex:R-DDI-5693617] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	POLL or POLM extends aligned DNA DSB ends to fill gaps
output	[Complex:R-DDI-5687362] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5687360
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-5693571] Nonhomologous End-Joining (NHEJ)
(inferredTo)	[Reaction:R-HSA-5687360] POLL or POLM extends aligned DNA DSB ends to fill gaps

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