DNA polymerases mu (POLM) and lambda (POLL) facilitate non-homologous end joining (NHEJ) of DNA double strand breaks (DSBs) by filling single strand (ss) gaps (usually 1- or 2- nucleotide gaps) present at DNA DSB ends positioned for ligation in the synaptic complex containing XRCC5:XRCC6 (Ku), PRKDC (DNA-PKcs), DCLRE1C (ARTEMIS), XRCC4:LIG4 and NHEJ1 (XLF) (Mahajan et al. 2002, Lee et al. 2004, Fan and Wu 2004, McElhinny et al. 2005, Davis et al. 2008).
Davis, BJ, Havener, JM, Ramsden, DA
Nick McElhinny, SA, Havener, JM, Garcia-Diaz, M, Juárez, R, Bebenek, K, Kee, BL, Blanco, L, Kunkel, TA, Ramsden, DA
Mahajan, KN, Nick McElhinny, SA, Mitchell, BS, Ramsden, DA
Fan, W, Wu, X
Lee, JW, Blanco, L, Zhou, T, Garcia-Diaz, M, Bebenek, K, Kunkel, TA, Wang, Z, Povirk, LF
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