SIRT6 deacetylates RBBP8

Stable Identifier
R-HSA-5685953
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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SIRT6 deacetylates RBBP8
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RBBP8 (CtIP) is constitutively acetylated in the absence of DNA damage on lysine residues K432, K526 and K604, and perhaps other lysines. DNA damage, through an unknown mechanism, triggers deacetylation of RBBP8 by SIRT6 protein lysine deacetylase. SIRT6-mediated deacetylation of RBBP8 is necessary for RBBP8-promoted resection of DNA double strand breaks (DSBs) (Kaidi et al. 2010).

Literature References
PubMed ID Title Journal Year
20829486 Human SIRT6 promotes DNA end resection through CtIP deacetylation

Kaidi, A, Weinert, BT, Choudhary, C, Jackson, SP

Science 2010
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
NAD-dependent protein deacetylase activity of SIRT6 [nucleoplasm]
Physical Entity
SIRT6 [nucleoplasm]
Activity
NAD-dependent protein deacetylase activity (0034979)
Orthologous Events
SIRT6 deacetylates RBBP8 (Bos taurus)
SIRT6 deacetylates RBBP8 (Caenorhabditis elegans)
SIRT6 deacetylates RBBP8 (Canis familiaris)
SIRT6 deacetylates RBBP8 (Danio rerio)
SIRT6 deacetylates RBBP8 (Gallus gallus)
SIRT6 deacetylates RBBP8 (Mus musculus)
SIRT6 deacetylates RBBP8 (Rattus norvegicus)
SIRT6 deacetylates RBBP8 (Sus scrofa)
SIRT6 deacetylates RBBP8 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-03-31)