RBBP8 (CtIP) is constitutively acetylated in the absence of DNA damage on lysine residues K432, K526 and K604, and perhaps other lysines. DNA damage, through an unknown mechanism, triggers deacetylation of RBBP8 by SIRT6 protein lysine deacetylase. SIRT6-mediated deacetylation of RBBP8 is necessary for RBBP8-promoted resection of DNA double strand breaks (DSBs) (Kaidi et al. 2010).
Kaidi, A, Weinert, BT, Choudhary, C, Jackson, SP
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