Deacteylation of RBBP8 (CtIP) upon DNA damage is dependent o...

created [InstanceEdit:5685957] Orlic-Milacic, Marija, 2015-03-31
dbId 5685964
displayName Deacteylation of RBBP8 (CtIP) upon DNA damage is dependent o...
modified [InstanceEdit:9851713] Orlic-Milacic, Marija, 2023-10-30
schemaClass Summation
text Deacteylation of RBBP8 (CtIP) upon DNA damage is dependent on SIRT6 protein lysine deacetylase and positively regulated by Lamin A (LMNA), where LMNA is thought to facilitate localization of SIRT6 to damaged DNA (Ghosh et al. 2015). SIRT6 depletion is associated with increased acetylateion of RBBP8 and impaired DNA repair (Cagnetta et al. 2018). Increased level of SIRT6 correlates with deacetylation of RBBP8 (Wang et al. 2022).
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