Reactome | LIG3 ligates remaining SSBs in MMEJ

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LIG3 ligates remaining SSBs in MMEJ Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5687672] DNA ligase activity of Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5687674] Orlic-Milacic, Marija, 2015-04-08
dbId	5687675
displayName	LIG3 ligates remaining SSBs in MMEJ
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5685939] HDR through MMEJ (alt-NHEJ) - Homo sapiens
input	[Complex:R-HSA-5687677] Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5687678] Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway [LiteratureReference:5687496] Homology and enzymatic requirements of microhomology-dependent alternative end joining [LiteratureReference:5687690] Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	LIG3 ligates remaining SSBs in MMEJ
orthologousEvent	[Reaction:R-DRE-5687675] LIG3 ligates remaining SSBs in MMEJ - Danio rerio [Reaction:R-SSC-5687675] LIG3 ligates remaining SSBs in MMEJ - Sus scrofa [Reaction:R-BTA-5687675] LIG3 ligates remaining SSBs in MMEJ - Bos taurus [Reaction:R-CFA-5687675] LIG3 ligates remaining SSBs in MMEJ - Canis familiaris [Reaction:R-RNO-5687675] LIG3 ligates remaining SSBs in MMEJ - Rattus norvegicus [Reaction:R-MMU-5687675] LIG3 ligates remaining SSBs in MMEJ - Mus musculus
output	[OtherEntity:R-ALL-5687670] dsDNA with base substitutions and inter-MMEJ deletion [nucleoplasm] [Complex:R-HSA-110338] LIG3:XRCC1 [nucleoplasm] [Complex:R-HSA-75164] MRN [nucleoplasm] [Complex:R-HSA-5684097] RBBP8 homotetramer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5687673] MRN recruits LIG3:XRCC1 to MMEJ sites - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5687675
summation	[Summation:5687683] The complex of DNA ligase 3 (LIG3) and XRCC1 is necessary fo...

Referrals

(hasEvent)

[Pathway:R-HSA-5685939] HDR through MMEJ (alt-NHEJ)