Reactome | IKBKB phosphorylates TPL2 (MAP3K8) at Ser400

Schema > Reaction > Entries

IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 Show undefined attributes

catalystActivity	[CatalystActivity:10405775] IkappaB kinase activity of CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10405783
displayName	IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
eventOf	[Pathway:R-BTA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-451638] NFKB1:MAP3K8:TNIP2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-5687880] NFKB1:p-S400-MAP3K8:TNIP2 [cytosol]
precedingEvent	[Reaction:R-BTA-451634] NFKB p105, TPL2 (COT) and ABIN2 form a stable complex - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5684275
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation
(inferredTo)	[Reaction:R-HSA-5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400

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