IKBKB phosphorylates TPL2 (MAP3K8) at Ser400

Stable Identifier
R-HSA-5684275
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
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The activity of tumor progression locus-2 (TPL2, also known as COT and MAP3K8) is regulated by means of phosphorylation (Stafford MJ et al., 2004; Cho J et al., 2005; Black TM et al., 2007; Robinson MJ et al., 2007). MAP3K8 undergoes phosphorylation on S400 in its C-terminal tail to activate MAP2Ks (MEK1/2) in LPS-stimulated macrophages (Robinson MJ et al., 2007). Different experimental systems have suggested that S400 is either autophosphosphorylated by MAPK3P8 or transphosphorylated (Kane LP et al., 2002; Robinson MJ et al., 2007; Roget K et al, 2012).
Literature References
PubMed ID Title Journal Year
22988300 IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400

Ley, SC, Mambole-Dema, A, Ben-Addi, A, Morrice, N, Roget, K, Abbott, DW, Janzen, J, Yang, HT, Gantke, T

Mol. Cell. Biol. 2012
16806191 Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62

Cohen, P, Morrice, NA, Peggie, MW, Stafford, MJ

FEBS Lett. 2006
Participants
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Output
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as an event of
Catalyst Activity

IkappaB kinase activity of p-S177,S181-IKKB:IKKA:NEMO [cytosol]

Physical Entity
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Homo sapiens)
Activity
IkappaB kinase activity (GO:0008384)
Orthologous Events
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
Authored
Shamovsky, V  (2015-05-13)
Reviewed
Jupe, S  (2015-04-14)
DeCicco-Skinner, KL  (2015-08-21)
Created
Shamovsky, V  (2015-03-20)
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