The activity of tumor progression locus-2 (TPL2, also known as COT and MAP3K8) is regulated by means of phosphorylation. MAP3K8 undergoes phosphorylated on S400 in its C-terminal tail to activate MAP2Ks (MEK1/2) following LPS stimulation of macrophages. Different experimental systems have suggested that S400 is either autophosphosphorylated by MAPK3P8 (IL-1?-stimulated IL-1R-293T cells) or transphosphorylated by an unknown kinase (LPS-stimulated RAW264.7 macrophages).
Roget, K, Ben-Addi, A, Mambole-Dema, A, Gantke, T, Yang, HT, Janzen, J, Morrice, N, Abbott, DW, Ley, SC
Handoyo, H, Stafford, MJ, McManus, E, Baltzis, D, Peggie, M, Cohen, P
Stafford, MJ, Morrice, NA, Peggie, MW, Cohen, P
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