IKBKB phosphorylates TPL2 (MAP3K8) at Ser400

Stable Identifier
R-HSA-5684275
Type
Reaction [transition]
Species
Homo sapiens
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The activity of tumor progression locus-2 (TPL2, also known as COT and MAP3K8) is regulated by means of phosphorylation. MAP3K8 undergoes phosphorylated on S400 in its C-terminal tail to activate MAP2Ks (MEK1/2) following LPS stimulation of macrophages. Different experimental systems have suggested that S400 is either autophosphosphorylated by MAPK3P8 (IL-1?-stimulated IL-1R-293T cells) or transphosphorylated by an unknown kinase (LPS-stimulated RAW264.7 macrophages).

Literature References
PubMed ID Title Journal Year
22988300 I?B kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400

Roget, K, Ben-Addi, A, Mambole-Dema, A, Gantke, T, Yang, HT, Janzen, J, Morrice, N, Abbott, DW, Ley, SC

Mol. Cell. Biol. 2012
19754427 IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

Handoyo, H, Stafford, MJ, McManus, E, Baltzis, D, Peggie, M, Cohen, P

Biochem. J. 2009
16806191 Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62

Stafford, MJ, Morrice, NA, Peggie, MW, Cohen, P

FEBS Lett. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
IkappaB kinase activity of IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol]
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Activity
Orthologous Events
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