Reactome | APBB1 and MAPK8 bind diphosphorylated H2AFX

Schema > Reaction > Entries

APBB1 and MAPK8 bind diphosphorylated H2AFX Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10405679
displayName	APBB1 and MAPK8 bind diphosphorylated H2AFX
eventOf	[Pathway:R-BTA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5683986] APBB1 and MAPK8 bind diphosphorylated H2AFX - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-5683987] APBB1 [nucleoplasm] [Complex:R-BTA-5683952] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-216349] phospho-MAPK8 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	APBB1 and MAPK8 bind diphosphorylated H2AFX
output	[Complex:R-BTA-5683988] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm]
precedingEvent	[Reaction:R-BTA-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5683986
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(inferredTo)	[Reaction:R-HSA-5683986] APBB1 and MAPK8 bind diphosphorylated H2AFX