APBB1 and MAPK8 bind diphosphorylated H2AFX

Stable Identifier
R-HSA-5683986
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

In the absence of sufficient EYA1-4 activity, APBB1 (FE65) binds diphosphorylated H2AFX and recruits MAPK8 (JNK1) to H2AFX. This triggers pro-apoptotic signaling and targets the affected cell for apoptosis instead of DNA repair (Cook et al. 2009).

Literature References
PubMed ID Title Journal Year
19234442 Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

Cook, PJ, Ju, BG, Telese, F, Wang, X, Glass, CK, Rosenfeld, MG

Nature 2009
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