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APBB1 and MAPK8 bind diphosphorylated H2AFX
Stable Identifier
R-HSA-5683986
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Homo sapiens)
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In the absence of sufficient EYA1-4 activity, APBB1 (FE65) binds diphosphorylated H2AFX and recruits MAPK8 (JNK1) to H2AFX. This triggers pro-apoptotic signaling and targets the affected cell for apoptosis instead of DNA repair (Cook et al. 2009).
Literature References
PubMed ID
Title
Journal
Year
19234442
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
Telese, F
,
Wang, X
,
Cook, PJ
,
Rosenfeld, MG
,
Glass, CK
,
Ju, BG
Nature
2009
Participants
Input
APBB1 [nucleoplasm]
(Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
(Homo sapiens)
p-T,Y-MAPK8 [nucleoplasm]
(Homo sapiens)
Output
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
Orthologous Events
APBB1 and MAPK8 bind diphosphorylated H2AFX (Bos taurus)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Canis familiaris)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Gallus gallus)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Mus musculus)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Rattus norvegicus)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Sus scrofa)
Authored
Orlic-Milacic, M (2015-05-12)
Reviewed
Borowiec, JA (2015-06-12)
Created
Orlic-Milacic, M (2015-03-17)
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