Reactome | Cytosolic DUSPs dephosphorylate MAPKs

Schema > Reaction > Entries

Cytosolic DUSPs dephosphorylate MAPKs Show undefined attributes

authored	[InstanceEdit:5675264] Rothfels, Karen, 2015-02-15
catalystActivity	[CatalystActivity:5675370] protein tyrosine/serine/threonine phosphatase activity of cytosolic MAPK DUSPs [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5675378] Rothfels, Karen, 2015-02-15
dbId	5675376
diseaseReaction	[FailedReaction:R-HSA-9652816] Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs - Homo sapiens
displayName	Cytosolic DUSPs dephosphorylate MAPKs
edited	[InstanceEdit:5675264] Rothfels, Karen, 2015-02-15
eventOf	[Pathway:R-HSA-5675221] Negative regulation of MAPK pathway - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-HSA-5674340] p-T,Y MAPK monomers and dimers [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5673943] ERK1/2 MAP kinases: structure, function, and regulation [LiteratureReference:5675330] The dual-specificity MAP kinase phosphatases: critical roles in development and cancer [LiteratureReference:5675326] Regulation of MAP kinases by MAP kinase phosphatases
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Cytosolic DUSPs dephosphorylate MAPKs
orthologousEvent	[Reaction:R-DDI-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Dictyostelium discoideum [Reaction:R-CEL-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Caenorhabditis elegans [Reaction:R-DME-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Drosophila melanogaster [Reaction:R-GGA-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Gallus gallus [Reaction:R-XTR-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Xenopus tropicalis [Reaction:R-DRE-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Danio rerio [Reaction:R-SSC-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Sus scrofa [Reaction:R-BTA-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Bos taurus [Reaction:R-CFA-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Canis familiaris [Reaction:R-RNO-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Rattus norvegicus [Reaction:R-MMU-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Mus musculus
output	[DefinedSet:R-HSA-5675361] MAPK monomers and dimers [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5675376
summation	[Summation:5675377] MAPKs are inactivated by dephosphorylation of the activation...

Referrals

(normalReaction)	[FailedReaction:R-HSA-9652816] Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs
(hasEvent)	[Pathway:R-HSA-5675221] Negative regulation of MAPK pathway [Pathway:R-HSA-112409] RAF-independent MAPK1/3 activation