MAPKs are inactivated by dephosphorylation of the activation...

created [InstanceEdit:5675378] Rothfels, Karen, 2015-02-15
dbId 5675377
displayName MAPKs are inactivated by dephosphorylation of the activation...
modified [InstanceEdit:5678723] Rothfels, Karen, 2015-02-26
schemaClass Summation
text MAPKs are inactivated by dephosphorylation of the activation loop T and Y residues by dual-specificity MAPK phosphatases (DUSPs) (reviewed in Roskoski, 2012b). Cytosolic MAPKs are dephosphorylated by the MAPK-specific class II DUSPs 6,7 and 9, but may also be dephosphorylated by cytosolic forms of class III DUSPs 8, 10 and 16, which preferentially dephosphorylate p38 and JNK MAP kinases (reviewed in Bermudez et al, 2010; Kandoh and Nishida, 2007).
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