RAC1:GTP:FMNL1 binds profilin:G-actin

Stable Identifier
R-HSA-5665659
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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FMNL1, activated by binding to GTP-bound RAC1, binds actin-associated profilins PFN1 and PFN2 through the proline-rich FH1 domain of FMNL1 (Yayoshi-Yamamoto et al. 2000). The interaction with actin is achieved through the FH2 domain of FMNL1 (Romero et al. 2004, Kovar et al. 2006, Kuhn and Geyer 2014). FMNL1 and profilin-mediated reorganization of actin cytoskeleton is involved in the formation of lamellipodia, which regulates the motility of macrophages (Yayoshi-Yamamoto et al. 2000). FMNL1 was shown to regulate the structure of the Golgi complex, where different transcriptional isoforms of FMNL1 may play different roles (Colon-Franco et al. 2011).

Literature References
PubMed ID Title Journal Year
21868368 Dynamic remodeling of the actin cytoskeleton by FMNL1? is required for structural maintenance of the Golgi complex

Colón-Franco, JM, Gomez, TS, Billadeau, DD

J. Cell. Sci. 2011
15507212 Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis

Romero, S, Le Clainche, C, Didry, D, Egile, C, Pantaloni, D, Carlier, MF

Cell 2004
24914801 Formins as effector proteins of Rho GTPases

Kühn, S, Geyer, M

Small GTPases 2014
16439214 Control of the assembly of ATP- and ADP-actin by formins and profilin

Kovar, DR, Harris, ES, Mahaffy, R, Higgs, HN, Pollard, TD

Cell 2006
10958683 FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages

Yayoshi-Yamamoto, S, Taniuchi, I, Watanabe, T

Mol. Cell. Biol. 2000
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