Reactome | Translesion synthesis by POLK

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Translesion synthesis by POLK Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912856
displayName	Translesion synthesis by POLK
eventOf	[Pathway:R-DME-110313] Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:10327] error-prone translesion synthesis
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-5655892] POLK incorporates dNMP opposite to damaged DNA base - Drosophila melanogaster [Reaction:R-DME-5655965] POLK and POLZ cooperate in elongation of mispaired primer termini - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-5655862] Translesion synthesis by POLK - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Translesion synthesis by POLK Translesion Synthesis by DNA Polymerase Kappa
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5655862
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-110313] Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
(inferredTo)	[Pathway:R-HSA-5655862] Translesion synthesis by POLK

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