Once recruited to the activated receptor, PI3K phosphorylate...

created [InstanceEdit:1384552] Rothfels, K, 2011-07-06
dbId 1384553
displayName Once recruited to the activated receptor, PI3K phosphorylate...
modified [InstanceEdit:2085645] Rothfels, K, 2012-02-05
schemaClass Summation
text Once recruited to the activated receptor, PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling. PI3K signaling has been demonstrated in ZMYM2-, FOP- and BCR-FGFR1 fusions (Chen, 2004; Demiroglu, 2001; Guasch, 2001), as well as downstream of a number of other FGFR mutants (see for instance, Byron, 2008; Kunii, 2008; Agazie, 2003; Takeda, 2007).
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