The ubiquitin ligase CBL exists in a complex with GRB2 and i...

created [InstanceEdit:1268283] Rothfels, K, 2011-05-09
dbId 1268284
displayName The ubiquitin ligase CBL exists in a complex with GRB2 and i...
literatureReference
modified [InstanceEdit:1549618] Rothfels, K, 2011-08-30
schemaClass Summation
text The ubiquitin ligase CBL exists in a complex with GRB2 and is recruited to tyrosine-phosphorylated FRS2 after FGF stimulation. In addition to promoting the ubiquitination, endocytosis, and degradation of the activated receptor complex, recruitment of the p-CBL:GRB2 complex seems to attenuate FGFR signaling by competing with GRB2:SOS1 for binding to the direct GRB2-binding sites on p-FRS2.
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