p-CBL:GRB2 binds p-FRS2:activated FGFR4

Stable Identifier
R-HSA-5654734
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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p-CBL:GRB2 binds p-FRS2:activated FGFR4
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The ubiquitin ligase CBL exists in a complex with GRB2 and is recruited to tyrosine-phosphorylated FRS2 after FGF stimulation. In addition to promoting the ubiquitination, endocytosis, and degradation of the activated receptor complex, recruitment of the p-CBL:GRB2 complex seems to attenuate FGFR signaling by competing with GRB2:SOS1 for binding to the direct GRB2-binding sites on p-FRS2.
Literature References
PubMed ID Title Journal Year
11997436 FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl

Wong, A, Lee, A, Lamothe, B, Schlessinger, J, Lax, I

Proc Natl Acad Sci U S A 2002
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Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2014-12-04)
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