FGFR1-amplified lung cancer and breast cancer cells show str...

created [InstanceEdit:1982063] Rothfels, K, 2011-11-09
dbId 1982064
displayName FGFR1-amplified lung cancer and breast cancer cells show str...
modified [InstanceEdit:2085580] Rothfels, K, 2012-02-03
schemaClass Summation
text FGFR1-amplified lung cancer and breast cancer cells show strong phosphorylation of FGFR1 and do not show elevated levels of FGF ligand, suggesting that these receptors can undergo ligand-independent activation. Phosphorylation is enhanced in the presence of exogenous ligand, supporting the notion that overexpressed FGFR1 can be activated by both ligand- and ligand-independent pathways (Koziczak, 2004; Dutt, 2008; Weiss, 2010). The biochemical consequences of overexpression of FGFR1 in other cancer types remain to be determined (reviewed in Turner and Gross, 2010; Wesche, 2011.
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