Reactome | RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA

Schema > Reaction > Entries

RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA Show undefined attributes

catalystActivity	[CatalystActivity:10402851] ubiquitin-protein transferase activity of RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10402853
displayName	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA
eventOf	[Pathway:R-BTA-110314] Recognition of DNA damage by PCNA-containing replication complex - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5655481] USP1:WDR48 binds monoUb:K164-PCNA - Bos taurus [Reaction:R-BTA-110307] REV1 binds AP-dsDNA - Bos taurus [Reaction:R-BTA-110316] POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template - Bos taurus
inferredFrom	[Reaction:R-HSA-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Homo sapiens
input	[Complex:R-BTA-5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] [DefinedSet:R-BTA-68524] Ub [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA
output	[Complex:R-BTA-5652003] MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] [CandidateSet:R-BTA-5651800] POLD,POLE [nucleoplasm] [DefinedSet:R-BTA-5655459] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm]
precedingEvent	[Reaction:R-BTA-5652005] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-5652009
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-110314] Recognition of DNA damage by PCNA-containing replication complex
(precedingEvent)	[Reaction:R-BTA-5655481] USP1:WDR48 binds monoUb:K164-PCNA [Reaction:R-BTA-110307] REV1 binds AP-dsDNA [Reaction:R-BTA-110316] POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template
(inferredTo)	[Reaction:R-HSA-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA