Reactome | RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm]

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RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:5652007] ubiquitin-protein transferase activity of RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-HSA-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Homo sapiens
created	[InstanceEdit:5651999] Orlic-Milacic, Marija, 2014-11-26
dbId	5651985
displayName	RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm]
hasComponent	[Complex:R-HSA-5651995] PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] [DefinedSet:R-HSA-5655459] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] - Mus musculus [Complex:R-RNO-5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] - Canis familiaris [Complex:R-BTA-5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] - Bos taurus [Complex:R-SSC-5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] - Sus scrofa [Complex:R-DRE-5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] - Danio rerio [Complex:R-GGA-5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] - Gallus gallus [Complex:R-DME-5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] - Caenorhabditis elegans [Complex:R-SPO-5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] - Schizosaccharomyces pombe
isChimeric	false
literatureReference	[LiteratureReference:5651998] RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO [LiteratureReference:5651996] Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a [LiteratureReference:5651988] Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification
maxDepth	6
modified	[InstanceEdit:5655465] Orlic-Milacic, Marija, 2014-12-05
name	RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template
producedByEvent	[Reaction:R-HSA-5652005] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5651985
updateTrackers	[UpdateTracker:9894544] Update Tracker - [Complex:5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] - v57:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9894544] Update Tracker - [Complex:5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] - v57:[updateContainedComponent]
(output)	[Reaction:R-HSA-5652005] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA
(input)	[Reaction:R-HSA-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA
(physicalEntity)	[CatalystActivity:5652007] ubiquitin-protein transferase activity of RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm]

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