Reactome | REV1 binds AP-dsDNA

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REV1 binds AP-dsDNA Show undefined attributes

authored	[InstanceEdit:110274] Gopinathrao, G, 2004-01-29 18:08:32
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110274] Gopinathrao, G, 2004-01-29 18:08:32
dbId	110307
displayName	REV1 binds AP-dsDNA
edited	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
eventOf	[Pathway:R-HSA-110312] Translesion synthesis by REV1 - Homo sapiens
followingEvent	[Reaction:R-HSA-110308] REV1 inserts dCMP opposite to AP sites in DNA - Homo sapiens
input	[Complex:R-HSA-5652039] MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3006726] REV1 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111301] The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light. [LiteratureReference:111303] The human REV1 gene codes for a DNA template-dependent dCMP transferase. [LiteratureReference:5652041] A ubiquitin-binding motif in the translesion DNA polymerase Rev1 mediates its essential functional interaction with ubiquitinated proliferating cell nuclear antigen in response to DNA damage [LiteratureReference:5652047] Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases eta and REV1
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	REV1 binds AP-dsDNA
orthologousEvent	[Reaction:R-PFA-110307] REV1 binds AP-dsDNA - Plasmodium falciparum [Reaction:R-SPO-110307] REV1 binds AP-dsDNA - Schizosaccharomyces pombe [Reaction:R-CEL-110307] REV1 binds AP-dsDNA - Caenorhabditis elegans [Reaction:R-DME-110307] REV1 binds AP-dsDNA - Drosophila melanogaster [Reaction:R-GGA-110307] REV1 binds AP-dsDNA - Gallus gallus [Reaction:R-DRE-110307] REV1 binds AP-dsDNA - Danio rerio [Reaction:R-SSC-110307] REV1 binds AP-dsDNA - Sus scrofa [Reaction:R-BTA-110307] REV1 binds AP-dsDNA - Bos taurus [Reaction:R-CFA-110307] REV1 binds AP-dsDNA - Canis familiaris [Reaction:R-RNO-110307] REV1 binds AP-dsDNA - Rattus norvegicus [Reaction:R-MMU-110307] REV1 binds AP-dsDNA - Mus musculus
output	[Complex:R-HSA-110283] REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5663080] Borowiec, James, 2015-01-07
revised	[InstanceEdit:5652011] Orlic-Milacic, Marija, 2014-11-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-110307
summation	[Summation:178513] REV1 is a deoxycytidyl transferase that belongs to the DNA p...
updateTrackers	[UpdateTracker:9791884] Update Tracker - [Reaction:110307] REV1 binds AP-dsDNA - v25:[add_removeInput] [UpdateTracker:9787967] Update Tracker - [Reaction:110307] REV1 binds AP-dsDNA - v44:[add_removeInput] [UpdateTracker:9785496] Update Tracker - [Reaction:110307] REV1 binds AP-dsDNA - v52:[addLiteratureReference, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791884] Update Tracker - [Reaction:110307] REV1 binds AP-dsDNA - v25:[add_removeInput] [UpdateTracker:9787967] Update Tracker - [Reaction:110307] REV1 binds AP-dsDNA - v44:[add_removeInput] [UpdateTracker:9785496] Update Tracker - [Reaction:110307] REV1 binds AP-dsDNA - v52:[addLiteratureReference, add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-110312] Translesion synthesis by REV1
(precedingEvent)	[Reaction:R-HSA-110308] REV1 inserts dCMP opposite to AP sites in DNA

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