SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)

Stable Identifier
R-HSA-5651654
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SUV420H1, SUV420H2, (SMYD3) methylate methyl-lysine-21 of histone H4 (H4K20), SUV420H1, SUV420H2, (SMYD3) methylate Me2K21-histone H4 (H4K20), SUV420H1, SUV420H2, (SMYD3) methylate Me2K21-histone H4
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The di- and tri-methylation of lysine-21 of histone H4 (H4K20) are performed by SUV420H1 (KMT5B), SUV420H2 (KMT5C) and possibly SMYD3 (KMT3E) (Foreman et al. 2011). Trimethylation is associated with heterochromatin formation and gene repression (Schotta et al. 2004). Monomethylation is performed by SETD8 (KMT5A) (Yin et al. 2005).
Literature References
PubMed ID Title Journal Year
15145825 A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

Jenuwein, T, Reinberg, D, Sengupta, R, Ebert, A, Schotta, G, Reuter, G, Sarma, K, Lachner, M

Genes Dev. 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

histone H4 methyltransferase activity of SUV420H1,SUV420H2,(SMYD3) [nucleoplasm]

Physical Entity
SUV420H1,SUV420H2,(SMYD3) [nucleoplasm] (Homo sapiens)
Activity
histone H4 methyltransferase activity (GO:0140939)
Orthologous Events
SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Bos taurus)
SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Canis familiaris)
SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Danio rerio)
SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Drosophila melanogaster)
SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Gallus gallus)
SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Mus musculus)
SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Rattus norvegicus)
SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Schizosaccharomyces pombe)
SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Sus scrofa)
Authored
Jupe, S  (2014-11-13)
Reviewed
Motamedi, M  (2014-11-17)
Created
Jupe, S  (2014-11-24)
Cite Us!