Reactome | SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)

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SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) Show undefined attributes

catalystActivity	[CatalystActivity:10879932] histone H4 methyltransferase activity of SUV420H1,SUV420H2,(SMYD3) [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10879934
displayName	SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)
eventOf	[Pathway:R-DME-3214841] PKMTs methylate histone lysines - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Homo sapiens
input	[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [EntityWithAccessionedSequence:R-DME-5423110] His4:CG33889 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) SUV420H1, SUV420H2, (SMYD3) methylate methyl-lysine-21 of histone H4 (H4K20) SUV420H1, SUV420H2, (SMYD3) methylate Me2K21-histone H4 (H4K20) SUV420H1, SUV420H2, (SMYD3) methylate Me2K21-histone H4
output	[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [EntityWithAccessionedSequence:R-DME-5651652] His4:CG33889 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5651654
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-3214841] PKMTs methylate histone lysines
(inferredTo)	[Reaction:R-HSA-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)

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