Reactome | GLI proteins bind PTCH1 gene

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GLI proteins bind PTCH1 gene Show undefined attributes

authored	[InstanceEdit:5633210] Rothfels, Karen, 2014-10-30
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5635849] Rothfels, Karen, 2014-11-07
dbId	5635848
displayName	GLI proteins bind PTCH1 gene
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5635851] GLI proteins bind promoters of Hh responsive genes to promote transcription - Homo sapiens
input	[DefinedSet:R-HSA-5635077] 2p-GLI1,2,3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5612503] PTCH1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5612467] A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb [LiteratureReference:5612477] Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [LiteratureReference:5612485] Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis [LiteratureReference:5612471] Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site [LiteratureReference:5358220] Gli proteins in development and disease
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GLI proteins bind PTCH1 gene
output	[Complex:R-HSA-5635085] 2p-GLI:PTCH1 gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-5635841] GLI proteins are phosphorylated - Homo sapiens
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5635848
summation	[Summation:5635787] PTCH1 has been identified as a Hh-responsive target in a num...

Referrals

(hasEvent)

[Pathway:R-HSA-5635851] GLI proteins bind promoters of Hh responsive genes to promote transcription