Reactome | Hh-dependent expression of GLI1 gene

Schema > BlackBoxEvent > Entries

Hh-dependent expression of GLI1 gene Show undefined attributes

authored	[InstanceEdit:5633210] Rothfels, Karen, 2014-10-30
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:5635852] Rothfels, Karen, 2014-11-07
dbId	5635853
displayName	Hh-dependent expression of GLI1 gene
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5635851] GLI proteins bind promoters of Hh responsive genes to promote transcription - Homo sapiens
followingEvent	[Reaction:R-HSA-5635861] NUMB:ITCH binds GLI1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5617393] GLI1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5634889] All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3 [LiteratureReference:5609748] Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway [LiteratureReference:5609839] Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3 [LiteratureReference:5612467] A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb [LiteratureReference:5612477] Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [LiteratureReference:5612485] Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hh-dependent expression of GLI1 gene
output	[EntityWithAccessionedSequence:R-HSA-445457] GLI1 [cytosol]
precedingEvent	[Reaction:R-HSA-5635846] GLI proteins bind GLI1 gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-5635870] Positive gene expression regulation by '2p-GLI:GLI1 gene [nucleoplasm]'
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5635853
summation	[Summation:5635800] GLI1 expression is promoted by the binding of the full-lengt...

Referrals

(hasEvent)	[Pathway:R-HSA-5635851] GLI proteins bind promoters of Hh responsive genes to promote transcription
(precedingEvent)	[Reaction:R-HSA-5635861] NUMB:ITCH binds GLI1