Reactome | GLI proteins bind GLI1 gene

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GLI proteins bind GLI1 gene Show undefined attributes

authored	[InstanceEdit:5633210] Rothfels, Karen, 2014-10-30
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5635847] Rothfels, Karen, 2014-11-07
dbId	5635846
displayName	GLI proteins bind GLI1 gene
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5635851] GLI proteins bind promoters of Hh responsive genes to promote transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5635853] Hh-dependent expression of GLI1 gene - Homo sapiens
input	[DefinedSet:R-HSA-5635077] 2p-GLI1,2,3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5617393] GLI1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5634889] All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3 [LiteratureReference:5609748] Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway [LiteratureReference:5609839] Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3 [LiteratureReference:5612467] A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb [LiteratureReference:5612477] Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [LiteratureReference:5612485] Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis [LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GLI proteins bind GLI1 gene
output	[Complex:R-HSA-5635082] 2p-GLI:GLI1 gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-5635841] GLI proteins are phosphorylated - Homo sapiens
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5635846
summation	[Summation:5635798] GLI1 is a direct target of the GLI transcription factors and...

Referrals

(hasEvent)	[Pathway:R-HSA-5635851] GLI proteins bind promoters of Hh responsive genes to promote transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-5635853] Hh-dependent expression of GLI1 gene