TP53 (p53) directly stimulates transcription of mitochondria...

created [InstanceEdit:5632918] Orlic-Milacic, Marija, 2014-10-29
dbId 5632913
displayName TP53 (p53) directly stimulates transcription of mitochondria...
modified [InstanceEdit:8856030] Orlic-Milacic, Marija, 2016-02-08
schemaClass Summation
text TP53 (p53) directly stimulates transcription of mitochondrial glutaminase GLS2 under non-stress and stress conditions. Increased GLS2 levels lead to increased production of glutamate and alpha-ketoglutarate, increased mitochondrial respiration rate, and reduced ROS (reactive oxygen species) load through enhanced glutathione reduction (Hu et al. 2010).

Elevated GLS2 was associated with lower levels of intracellular ROS and a decrease in DNA oxidation. GLS2 knockdown resulted in higher ROS levels and was associated with stimulation of p53-induced cell death (Suzuki et al. 2010).

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