TP53 stimulates GLS2 transcription

Stable Identifier
R-HSA-5632924
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
mitochondrial matrix, nucleoplasm
ReviewStatus
5/5
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TP53 stimulates GLS2 transcription
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TP53 (p53) directly stimulates transcription of mitochondrial glutaminase GLS2 under non-stress and stress conditions. Increased GLS2 levels lead to increased production of glutamate and alpha-ketoglutarate, increased mitochondrial respiration rate, and reduced ROS (reactive oxygen species) load through enhanced glutathione reduction (Hu et al. 2010).

Elevated GLS2 was associated with lower levels of intracellular ROS and a decrease in DNA oxidation. GLS2 knockdown resulted in higher ROS levels and was associated with stimulation of p53-induced cell death (Suzuki et al. 2010).

Literature References
PubMed ID Title Journal Year
20378837 Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Zhang, C, Hu, W, Sun, Y, Wu, R, Levine, A, Feng, Z

Proc. Natl. Acad. Sci. U.S.A. 2010
20351271 Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Hosokawa, H, Poyurovsky, MV, Nagano, H, Mayama, T, Tanaka, T, Prives, C, Nakayama, T, Sato, E, Ohkubo, S, Lokshin, M, Suzuki, S, Nagao, T, Suzuki, Y, Yokote, K, Sugano, S, Tatsuno, I

Proc. Natl. Acad. Sci. U.S.A. 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TP53 Tetramer:GLS2 Gene [nucleoplasm] (Homo sapiens)
Active Unit
TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2014-12-23)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Wang, PY  (2014-12-30)
Hwang, PM  (2014-12-30)
Kang, JG  (2014-12-30)
Created
Orlic-Milacic, M  (2014-10-29)
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