TP53 stimulates transcription of RRM2B gene

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R-HSA-5632892
Type
Reaction [omitted]
Species
Homo sapiens
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TP53 (p53) directly stimulates transcription of RRM2B gene (p53R2), which encodes a critical subunit of the ribonucleotide reductase complex (Tanaka et al. 2000), responsible for de novo conversion of ribonucleotides (NTPs) to deoxyribonucleotides (dNTPs). This regulation provides a direct mechanism through which TP53 contributes to DNA synthesis/repair. Mutations in RRM2B gene cause severe mitochondrial DNA depletion (Bourdon et al. 2007, Kulawiec et al. 2009).

Literature References
PubMed ID Title Journal Year
17486094 Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion

Bourdon, A, Minai, L, Serre, V, Jais, JP, Sarzi, E, Aubert, S, Chrétien, D, de Lonlay, P, Paquis-Flucklinger, V, Arakawa, H, Nakamura, Y, Munnich, A, Rötig, A

Nat. Genet. 2007
10716435 A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

Tanaka, H, Arakawa, H, Yamaguchi, T, Shiraishi, K, Fukuda, S, Matsui, K, Takei, Y, Nakamura, Y

Nature 2000
19439913 p53 regulates mtDNA copy number and mitocheckpoint pathway

Kulawiec, M, Ayyasamy, V, Singh, KK

J Carcinog 2009
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