TP53 stimulates transcription of RRM2B gene

Stable Identifier
R-HSA-5632892
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TP53 stimulates transcription of RRM2B gene
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TP53 (p53) directly stimulates transcription of RRM2B gene (p53R2), which encodes a critical subunit of the ribonucleotide reductase complex (Tanaka et al. 2000), responsible for de novo conversion of ribonucleotides (NTPs) to deoxyribonucleotides (dNTPs). This regulation provides a direct mechanism through which TP53 contributes to DNA synthesis/repair. Mutations in RRM2B gene cause severe mitochondrial DNA depletion (Bourdon et al. 2007, Kulawiec et al. 2009).
Literature References
PubMed ID Title Journal Year
10716435 A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

Arakawa, H, Nakamura, Y, Matsui, K, Takei, Y, Shiraishi, K, Fukuda, S, Tanaka, H, Yamaguchi, T

Nature 2000
17486094 Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion

Arakawa, H, Munnich, A, Aubert, S, Serre, V, Chrétien, D, Rötig, A, Bourdon, A, Sarzi, E, Minai, L, de Lonlay, P, Nakamura, Y, Jais, JP, Paquis-Flucklinger, V

Nat. Genet. 2007
19439913 p53 regulates mtDNA copy number and mitocheckpoint pathway

Kulawiec, M, Ayyasamy, V, Singh, KK

J Carcinog 2009
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
TP53 Tetramer:RRM2B Gene [nucleoplasm] (Homo sapiens)
Active Unit
TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2014-12-23)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Wang, PY  (2014-12-30)
Hwang, PM  (2014-12-30)
Kang, JG  (2014-12-30)
Created
Orlic-Milacic, M  (2014-10-29)
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