Reactome | RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)

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RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) Show undefined attributes

catalystActivity	[CatalystActivity:8866406] ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor of RNR (M1M2B) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8866407] D'Eustachio, Peter, 2016-03-31
dbId	8866405
displayName	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)
eventOf	[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-55729] GLRX [cytosol] [SimpleEntity:R-ALL-8866401] NDP(3-) [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111731] Structure and function of the radical enzyme ribonucleotide reductase [LiteratureReference:111733] Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells [LiteratureReference:111723] Thioredoxin and glutaredoxin systems [LiteratureReference:8866393] Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage [LiteratureReference:8866463] Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells [LiteratureReference:111734] Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase [LiteratureReference:111749] In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase [LiteratureReference:111743] The NMR solution structure of human glutaredoxin in the fully reduced form [LiteratureReference:111775] A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage [LiteratureReference:8866460] Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase [LiteratureReference:499990] A dityrosyl-diiron radical cofactor center is essential for human ribonucleotide reductases
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O
orthologousEvent	[Reaction:R-PFA-8866405] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) - Plasmodium falciparum [Reaction:R-CEL-8866405] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) - Caenorhabditis elegans [Reaction:R-XTR-8866405] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) - Xenopus tropicalis [Reaction:R-DRE-8866405] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) - Danio rerio [Reaction:R-SSC-8866405] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) - Sus scrofa [Reaction:R-BTA-8866405] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) - Bos taurus [Reaction:R-CFA-8866405] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) - Canis familiaris [Reaction:R-RNO-8866405] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) - Rattus norvegicus [Reaction:R-MMU-8866405] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-111740] 2xHC-GLRX [cytosol] [SimpleEntity:R-ALL-8866399] dNDP(3-) [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
precedingEvent	[Reaction:R-HSA-111746] glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) - Homo sapiens [BlackBoxEvent:R-HSA-5632892] TP53 stimulates transcription of RRM2B gene - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8866419] Negative regulation by 'dATP [cytosol]' [PositiveRegulation:R-HSA-8866467] Positive regulation by 'ATP [cytosol]'
releaseDate	2016-06-27
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8866405
summation	[Summation:8866464] Ribonucleotide reductase (RNR (M1M2B)) catalyzes the reducti...

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(hasEvent)

[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates

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