Reactome | Hh-Npp binds GAS1 and PTCH

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10057195
displayName	Hh-Npp binds GAS1 and PTCH
eventOf	[Pathway:R-MMU-5632681] Ligand-receptor interactions - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5632649] Hh-Npp binds GAS1 and PTCH - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-449167] Gas1 [plasma membrane] [CandidateSet:R-MMU-5362783] Hh-Npp [extracellular region] [EntityWithAccessionedSequence:R-MMU-5610415] Ptch1 [ciliary membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Hh-Npp binds GAS1 and PTCH
output	[Complex:R-MMU-5632592] Hh-Npp:GAS1:PTCH [ciliary membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5632649
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-5632681] Ligand-receptor interactions
(inferredTo)	[Reaction:R-HSA-5632649] Hh-Npp binds GAS1 and PTCH

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