Reactome | Hh-Npp binds GAS1 and PTCH

Hh-Npp binds GAS1 and PTCH

Stable Identifier

R-HSA-5632649

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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GAS1 is a vertebrate-specific Hh coreceptor that binds directly to Hh ligand to promote signaling (Martinelli and Fan, 2007; McLellan et al, 2008; Izzi et al, 2011; Pineda-Alvarez et al, 2012). GAS1 interacts directly with PTCH as well as BOC and CDON and contributes in an unclearly defined manner to Hh signal transduction (Martinelli and Fan, 2007; Allen et al, 2007; Izzi et al, 2011; Allen et al, 2011; reviewed in Sanchez-Arrones et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
17504940	Gas1 extends the range of Hedgehog action by facilitating its signaling Martinelli, DC, Fan, CM	Genes Dev.	2007
17504941	The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development Allen, BL, Tenzen, T, McMahon, AP	Genes Dev.	2007
21664577	Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation Izzi, L, Lévesque, M, Morin, S, Laniel, D, Wilkes, BC, Mille, F, Krauss, RS, McMahon, AP, Allen, BL, Charron, F	Dev. Cell	2011
21842183	Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH Pineda-Alvarez, DE, Roessler, E, Hu, P, Srivastava, K, Solomon, BD, Siple, CE, Fan, CM, Muenke, M	Hum. Genet.	2012
22326621	Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication Sanchez-Arrones, L, Cardozo, M, Nieto-Lopez, F, Bovolenta, P	Int. J. Biochem. Cell Biol.	2012
21664576	Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function Allen, BL, Song, JY, Izzi, L, Althaus, IW, Kang, JS, Charron, F, Krauss, RS, McMahon, AP	Dev. Cell	2011
18794898	The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla McLellan, JS, Zheng, X, Hauk, G, Ghirlando, R, Beachy, PA, Leahy, DJ	Nature	2008