Hh-Npp binds GAS1 and PTCH

Stable Identifier
R-HSA-5632649
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GAS1 is a vertebrate-specific Hh coreceptor that binds directly to Hh ligand to promote signaling (Martinelli and Fan, 2007; McLellan et al, 2008; Izzi et al, 2011; Pineda-Alvarez et al, 2012). GAS1 interacts directly with PTCH as well as BOC and CDON and contributes in an unclearly defined manner to Hh signal transduction (Martinelli and Fan, 2007; Allen et al, 2007; Izzi et al, 2011; Allen et al, 2011; reviewed in Sanchez-Arrones et al, 2012).

Literature References
PubMed ID Title Journal Year
17504941 The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development

Allen, BL, Tenzen, T, McMahon, AP

Genes Dev. 2007
17504940 Gas1 extends the range of Hedgehog action by facilitating its signaling

Martinelli, DC, Fan, CM

Genes Dev. 2007
21664577 Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation

Izzi, L, Lévesque, M, Morin, S, Laniel, D, Wilkes, BC, Mille, F, Krauss, RS, McMahon, AP, Allen, BL, Charron, F

Dev. Cell 2011
21842183 Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH

Pineda-Alvarez, DE, Roessler, E, Hu, P, Srivastava, K, Solomon, BD, Siple, CE, Fan, CM, Muenke, M

Hum. Genet. 2012
22326621 Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication

Sanchez-Arrones, L, Cardozo, M, Nieto-Lopez, F, Bovolenta, P

Int. J. Biochem. Cell Biol. 2012
21664576 Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function

Allen, BL, Song, JY, Izzi, L, Althaus, IW, Kang, JS, Charron, F, Krauss, RS, McMahon, AP

Dev. Cell 2011
18794898 The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

McLellan, JS, Zheng, X, Hauk, G, Ghirlando, R, Beachy, PA, Leahy, DJ

Nature 2008
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