GAS1 is a vertebrate-specific Hh coreceptor that binds directly to Hh ligand to promote signaling (Martinelli and Fan, 2007; McLellan et al, 2008; Izzi et al, 2011; Pineda-Alvarez et al, 2012). GAS1 interacts directly with PTCH as well as BOC and CDON and contributes in an unclearly defined manner to Hh signal transduction (Martinelli and Fan, 2007; Allen et al, 2007; Izzi et al, 2011; Allen et al, 2011; reviewed in Sanchez-Arrones et al, 2012).
Fan, CM, Martinelli, DC
Allen, BL, McMahon, AP, Tenzen, T
Charron, F, Morin, S, Krauss, RS, Allen, BL, Laniel, D, Lévesque, M, McMahon, AP, Mille, F, Wilkes, BC, Izzi, L
Muenke, M, Solomon, BD, Hu, P, Fan, CM, Srivastava, K, Roessler, E, Siple, CE, Pineda-Alvarez, DE
Nieto-Lopez, F, Cardozo, M, Bovolenta, P, Sanchez-Arrones, L
Charron, F, Song, JY, Krauss, RS, Allen, BL, McMahon, AP, Althaus, IW, Kang, JS, Izzi, L
Ghirlando, R, Beachy, PA, Zheng, X, Leahy, DJ, Hauk, G, McLellan, JS
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