GAS1 is a vertebrate-specific Hh coreceptor that binds direc...

created [InstanceEdit:5632422] Rothfels, Karen, 2014-10-28
dbId 5632423
displayName GAS1 is a vertebrate-specific Hh coreceptor that binds direc...
modified [InstanceEdit:5638119] Rothfels, Karen, 2014-11-13
schemaClass Summation
text GAS1 is a vertebrate-specific Hh coreceptor that binds directly to Hh ligand to promote signaling (Martinelli and Fan, 2007; McLellan et al, 2008; Izzi et al, 2011; Pineda-Alvarez et al, 2012). GAS1 interacts directly with PTCH as well as BOC and CDON and contributes in an unclearly defined manner to Hh signal transduction (Martinelli and Fan, 2007; Allen et al, 2007; Izzi et al, 2011; Allen et al, 2011; reviewed in Sanchez-Arrones et al, 2012).
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