TP53 stimulates expression of SESN1,2,3 genes

Stable Identifier
R-HSA-5629189
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TP53 stimulates expression of SESN1,2,3 genes
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Sestrins (SESN) are a small family of stress-sensitive gene that are conserved across several species. Mammals express three different SESN family members characterized as SESN1-3. Sestrin genes, SESN1, SESN2 and SESN3, are upregulated in response to TP53-mediated transcriptional regulation. SESN1 and SESN2 were classified as members of the growth arrest and DNA damage (GADD) gene family that can regulate cell growth and viability under different cellular pressures. In particular, p53 negatively modulates the mTOR pahtway via SESN1 and SESN2 upregulation (Feng 2010). SESN3 was identified shortly after SESN2 through in silico analysis and was found to be a target of the forkhead transcription factor (FOXO) family. A specific TP53 binding site on the human SESN3 promoter has not been identified yet, but was found in the rat ortholog (Velasco-Miguel et al. 1999, Budanov et al. 2002, Brynczka et al. 2007).
Literature References
PubMed ID Title Journal Year
9926927 PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

Velasco-Miguel, S, Buckbinder, L, Jean, P, Gelbert, L, Talbott, R, Laidlaw, J, Seizinger, B, Kley, N

Oncogene 1999
20182617 p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment

Feng, Z

Cold Spring Harb Perspect Biol 2010
17540029 NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation

Brynczka, C, Labhart, P, Merrick, BA

BMC Genomics 2007
12203114 Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

Budanov, AV, Shoshani, T, Faerman, A, Zelin, E, Kamer, I, Kalinski, H, Gorodin, S, Fishman, A, Chajut, A, Einat, P, Skaliter, R, Gudkov, AV, Chumakov, PM, Feinstein, E

Oncogene 2002
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
TP53 Tetramer:SESN1,2,3 Genes [nucleoplasm] (Homo sapiens)
Active Unit
TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2014-12-23)
Reviewed
Hwang, PM  (2014-12-30)
Kang, JG  (2014-12-30)
Wang, PY  (2014-12-30)
Inga, A  (2016-02-04)
Zaccara, S  (2016-02-04)
Created
Orlic-Milacic, M  (2014-10-24)
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