Sestrins (SESN) are a small family of stress-sensitive gene that are conserved across several species. Mammals express three different SESN family members characterized as SESN1-3. Sestrin genes, SESN1, SESN2 and SESN3, are upregulated in response to TP53-mediated transcriptional regulation. SESN1 and SESN2 were classified as members of the growth arrest and DNA damage (GADD) gene family that can regulate cell growth and viability under different cellular pressures. In particular, p53 negatively modulates the mTOR pahtway via SESN1 and SESN2 upregulation (Feng 2010). SESN3 was identified shortly after SESN2 through in silico analysis and was found to be a target of the forkhead transcription factor (FOXO) family. A specific TP53 binding site on the human SESN3 promoter has not been identified yet, but was found in the rat ortholog (Velasco-Miguel et al. 1999, Budanov et al. 2002, Brynczka et al. 2007).
Gelbert, L, Laidlaw, J, Talbott, R, Seizinger, B, Buckbinder, L, Jean, P, Kley, N, Velasco-Miguel, S
Feng, Z
Labhart, P, Brynczka, C, Merrick, BA
Feinstein, E, Gudkov, AV, Chajut, A, Kamer, I, Kalinski, H, Fishman, A, Shoshani, T, Skaliter, R, Budanov, AV, Chumakov, PM, Zelin, E, Einat, P, Faerman, A, Gorodin, S
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