Reactome | IQGAPs bind F-actin, which is inhibited by calmodulin

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IQGAPs bind F-actin, which is inhibited by calmodulin Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5626497] Orlic-Milacic, Marija, 2014-10-10
dbId	5626507
displayName	IQGAPs bind F-actin, which is inhibited by calmodulin
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-5626467] RHO GTPases activate IQGAPs - Homo sapiens
input	[Polymer:R-HSA-201877] F-actin [cytosol] [Complex:R-HSA-5626465] RAC1,CDC42:GTP:IQGAPs [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5626515] The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration [LiteratureReference:5626488] IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth [LiteratureReference:5626541] IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments [LiteratureReference:5626533] Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42 [LiteratureReference:5626534] The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	IQGAPs bind F-actin, which is inhibited by calmodulin
orthologousEvent	[Reaction:R-CEL-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Caenorhabditis elegans [Reaction:R-SCE-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Saccharomyces cerevisiae [Reaction:R-SPO-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Schizosaccharomyces pombe [Reaction:R-DDI-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Dictyostelium discoideum [Reaction:R-GGA-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Gallus gallus [Reaction:R-XTR-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Xenopus tropicalis [Reaction:R-DRE-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Danio rerio [Reaction:R-SSC-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Sus scrofa [Reaction:R-BTA-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Bos taurus [Reaction:R-CFA-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Canis familiaris [Reaction:R-RNO-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Rattus norvegicus [Reaction:R-MMU-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Mus musculus
output	[Complex:R-HSA-5626510] RAC1,CDC42:GTP:IQGAP:F-actin [plasma membrane]
precedingEvent	[Reaction:R-HSA-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-5626550] Negative regulation by 'RAC1:GTP,CDC42:GTP:IQGAPs:CALM1:4Ca2+ [plasma membrane]'
regulationReference	[RegulationReference:9642519] Negative regulation by 'RAC1:GTP,CDC42:GTP:IQGAPs:CALM1:4Ca2+ [plasma membrane]' The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5626507
summation	[Summation:5626525] IQGAP proteins IQGAP1, IQGAP2 and IQGAP3 bind F-actin filame...
systematicName	IQGAPs bind F-actin

Referrals

(hasEvent)

[Pathway:R-HSA-5626467] RHO GTPases activate IQGAPs

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