IQGAP proteins IQGAP1, IQGAP2 and IQGAP3 bind F-actin filaments through their calponin homology (CH) domain (Pelikan-Conchaudron et al. 2011, Wang et al. 2007, Bashour et al. 1997, Fukata et al. 1997, Brill et al. 1996). Human IQGAP1 is implicated in cell migration, through regulation of actin filaments (Pelikan-Conchaudron et al. 2011). The regulation of actin filaments by IQGAP2 and IQGAP3 is implicated in axon outgrowth in hippocampal neurons (Wang et al. 2007).
Binding of calmodulin to IQ repeats (isoleucine- and glutamine-rich motifs) of IQGAPs inhibits binding of IQGAPs to F-actin (Bashour et al. 1997, Pelikan-Conchaudron et al. 2011).
Kaibuchi, K, Arimura, N, Fukata, M, Yoshimura, T, Noritake, J, Nakagawa, M, Matsuura, Y, Itoh, N, Watanabe, T, Wang, S, Harada, T
Bloom, GS, Fullerton, AT, Hart, MJ, Bashour, AM
Carlier, MF, Didry, D, Pelikan-Conchaudron, A, Le Clainche, C
Li, S, Church, DM, Weissbach, L, Wasmuth, JJ, Lyman, CW, Snijders, AJ, Bernards, A, Brill, S
Kikuchi, A, Kaibuchi, K, Fukata, M, Kuroda, S, Nakamura, T, Shoji, I, Fujii, K, Matsuura, Y, Okawa, K, Iwamatsu, A
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