IQGAPs bind F-actin, which is inhibited by calmodulin

Stable Identifier
R-HSA-5626507
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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IQGAP proteins IQGAP1, IQGAP2 and IQGAP3 bind F-actin filaments through their calponin homology (CH) domain (Pelikan-Conchaudron et al. 2011, Wang et al. 2007, Bashour et al. 1997, Fukata et al. 1997, Brill et al. 1996). Human IQGAP1 is implicated in cell migration, through regulation of actin filaments (Pelikan-Conchaudron et al. 2011). The regulation of actin filaments by IQGAP2 and IQGAP3 is implicated in axon outgrowth in hippocampal neurons (Wang et al. 2007).

Binding of calmodulin to IQ repeats (isoleucine- and glutamine-rich motifs) of IQGAPs inhibits binding of IQGAPs to F-actin (Bashour et al. 1997, Pelikan-Conchaudron et al. 2011).

Literature References
PubMed ID Title Journal Year
9199170 IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments

Bashour, AM, Fullerton, AT, Hart, MJ, Bloom, GS

J. Cell Biol. 1997
17244649 IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth

Wang, S, Watanabe, T, Noritake, J, Fukata, M, Yoshimura, T, Itoh, N, Harada, T, Nakagawa, M, Matsuura, Y, Arimura, N, Kaibuchi, K

J. Cell. Sci. 2007
21730051 The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration

Pelikan-Conchaudron, A, Le Clainche, C, Didry, D, Carlier, MF

J. Biol. Chem. 2011
8756646 The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases

Brill, S, Li, S, Lyman, CW, Church, DM, Wasmuth, JJ, Weissbach, L, Bernards, A, Snijders, AJ

Mol. Cell. Biol. 1996
9368021 Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42

Fukata, M, Kuroda, S, Fujii, K, Nakamura, T, Shoji, I, Matsuura, Y, Okawa, K, Iwamatsu, A, Kikuchi, A, Kaibuchi, K

J. Biol. Chem. 1997
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