Reactome | GTP-bound RAC1 and CDC42 bind IQGAPs

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GTP-bound RAC1 and CDC42 bind IQGAPs Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5626466] Orlic-Milacic, Marija, 2014-10-09
dbId	5626469
displayName	GTP-bound RAC1 and CDC42 bind IQGAPs
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-5626467] RHO GTPases activate IQGAPs - Homo sapiens
followingEvent	[Reaction:R-HSA-5672329] IQGAP1 binds CLIP1 and microtubules - Homo sapiens [Reaction:R-HSA-5626549] IQGAPs bind CALM1 - Homo sapiens [Reaction:R-HSA-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Homo sapiens
input	[DefinedSet:R-HSA-389778] CDC42:GTP, RAC1:GTP [plasma membrane] [DefinedSet:R-HSA-5626373] IQGAP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5626508] Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1 [LiteratureReference:5626488] IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth [LiteratureReference:5626515] The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration [LiteratureReference:5626520] IQGAP1 is a component of Cdc42 signaling to the cytoskeleton [LiteratureReference:5626541] IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	GTP-bound RAC1 and CDC42 bind IQGAPs
orthologousEvent	[Reaction:R-CEL-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Caenorhabditis elegans [Reaction:R-SCE-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Saccharomyces cerevisiae [Reaction:R-SPO-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Schizosaccharomyces pombe [Reaction:R-DDI-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Dictyostelium discoideum [Reaction:R-GGA-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Gallus gallus [Reaction:R-XTR-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Xenopus tropicalis [Reaction:R-DRE-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Danio rerio [Reaction:R-SSC-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Sus scrofa [Reaction:R-BTA-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Bos taurus [Reaction:R-CFA-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Canis familiaris [Reaction:R-RNO-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Rattus norvegicus [Reaction:R-MMU-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Mus musculus
output	[Complex:R-HSA-5626465] RAC1,CDC42:GTP:IQGAPs [plasma membrane]
precedingEvent	[Reaction:R-HSA-8848618] Activation of RAC1 by the PXN:CRK complex - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5626469
summation	[Summation:5626522] IQGAP proteins IQGAP1, IQGAP2 and IQGAP3, bind Rho GTPases R...
systematicName	RAC1:GTP,CDC42:GTP bind IQGAPs

Referrals

(precedingEvent)	[Reaction:R-HSA-5672329] IQGAP1 binds CLIP1 and microtubules [Reaction:R-HSA-5626549] IQGAPs bind CALM1 [Reaction:R-HSA-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin
(hasEvent)	[Pathway:R-HSA-5626467] RHO GTPases activate IQGAPs

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