Reactome | IQGAPs bind F-actin, which is inhibited by calmodulin

Schema > Reaction > Entries

IQGAPs bind F-actin, which is inhibited by calmodulin Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10516109
displayName	IQGAPs bind F-actin, which is inhibited by calmodulin
eventOf	[Pathway:R-SSC-5626467] RHO GTPases activate IQGAPs - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin - Homo sapiens
input	[Polymer:R-SSC-201877] F-actin [cytosol] [Complex:R-SSC-5626465] RAC1,CDC42:GTP:IQGAPs [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IQGAPs bind F-actin, which is inhibited by calmodulin
output	[Complex:R-SSC-5626510] RAC1,CDC42:GTP:IQGAP:F-actin [plasma membrane]
precedingEvent	[Reaction:R-SSC-5626469] GTP-bound RAC1 and CDC42 bind IQGAPs - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5626507
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5626467] RHO GTPases activate IQGAPs
(inferredTo)	[Reaction:R-HSA-5626507] IQGAPs bind F-actin, which is inhibited by calmodulin

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