Reactome | KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters

Schema > Reaction > Entries

KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
catalystActivity	[CatalystActivity:5625851] histone demethylase activity of p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643256] histone demethylase activity of p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5625852] Orlic-Milacic, Marija, 2014-10-08
dbId	5625848
displayName	KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters
edited	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24
eventOf	[Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Homo sapiens
followingEvent	[Reaction:R-HSA-5625870] KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters - Homo sapiens
input	[SimpleEntity:R-ALL-113671] 2OG [nucleoplasm] [SimpleEntity:R-ALL-113685] O2 [nucleoplasm] [Complex:R-HSA-5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5625775] Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation [LiteratureReference:4687010] LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters
orthologousEvent	[Reaction:R-DME-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters - Drosophila melanogaster [Reaction:R-XTR-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters - Xenopus tropicalis [Reaction:R-DRE-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters - Danio rerio [Reaction:R-SSC-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters - Sus scrofa [Reaction:R-BTA-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters - Bos taurus [Reaction:R-CFA-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters - Canis familiaris [Reaction:R-RNO-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters - Rattus norvegicus
output	[SimpleEntity:R-ALL-29478] CH2O [nucleoplasm] [SimpleEntity:R-ALL-159942] CO2 [nucleoplasm] [Complex:R-HSA-5625863] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] [SimpleEntity:R-ALL-159939] SUCCA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5625848
summation	[Summation:5625866] PKN1-mediated phosphorylation of histone H3 threonine residu...
systematicName	Complexed KDM1A demethylates complexed p-T12,Me2K-10-H3

Referrals

(hasEvent)	[Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
(precedingEvent)	[Reaction:R-HSA-5625870] KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters