Reactome | KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters

KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters

Stable Identifier

R-HSA-5625848

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters

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PKN1-mediated phosphorylation of histone H3 threonine residue T12 (also labeled in literature as Thr11) enables demethylation of histone H3 lysine K10 (also labeled in literature as K9) by demethylase KDM1A (LSD1) (Metzger et al. 2008). KDM1A acts on dimethylated and monomethylated H3K9 at AR-regulated promoters (Metzger et al. 2005), so it is shown that demethylation of dimethylated H3K9 (Me2K-10-H3) by KDM1A happens after demethylation of trimethylated H3K9 (Me3K-10-H3) by KDM4C (JMJD2C).

Literature References

PubMed ID	Title	Journal	Year
16079795	LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription Metzger, E, Wissmann, M, Yin, N, Müller, JM, Schneider, R, Peters, AH, Günther, T, Buettner, R, Schüle, R	Nature	2005
18066052	Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation Metzger, E, Yin, N, Wissmann, M, Kunowska, N, Fischer, K, Friedrichs, N, Patnaik, D, Higgins, JM, Potier, N, Scheidtmann, KH, Buettner, R, Schüle, R	Nat. Cell Biol.	2008