Reactome | p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm]

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p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:5625851] histone demethylase activity of p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-HSA-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters - Homo sapiens
created	[InstanceEdit:5625852] Orlic-Milacic, Marija, 2014-10-08
dbId	5625850
displayName	p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-996769] KDM1A [nucleoplasm] [Complex:R-HSA-5625789] p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-RNO-5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] - Canis familiaris [Complex:R-BTA-5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] - Bos taurus [Complex:R-SSC-5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] - Sus scrofa [Complex:R-DRE-5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] - Danio rerio [Complex:R-XTR-5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] - Xenopus tropicalis [Complex:R-DME-5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] - Drosophila melanogaster
isChimeric	false
literatureReference	[LiteratureReference:5625775] Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
maxDepth	6
modified	[InstanceEdit:5625861] Orlic-Milacic, Marija, 2014-10-08
name	p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A
producedByEvent	[Reaction:R-HSA-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5625850
updateTrackers	[UpdateTracker:9902222] Update Tracker - [Complex:5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] - v77:[updateContainedComponent] [UpdateTracker:9904495] Update Tracker - [Complex:5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] - v84:[updateContainedComponent] [UpdateTracker:9894655] Update Tracker - [Complex:5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] - v57:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9902222] Update Tracker - [Complex:5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] - v77:[updateContainedComponent] [UpdateTracker:9904495] Update Tracker - [Complex:5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] - v84:[updateContainedComponent] [UpdateTracker:9894655] Update Tracker - [Complex:5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] - v57:[updateContainedComponent]
(output)	[Reaction:R-HSA-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters
(input)	[Reaction:R-HSA-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters
(physicalEntity)	[CatalystActivity:5625851] histone demethylase activity of p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm]

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