Reactome | KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters

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KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters Show undefined attributes

catalystActivity	[CatalystActivity:10613829] histone demethylase activity of p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10613831
displayName	KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters
eventOf	[Pathway:R-DRE-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5625870] KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters - Danio rerio
inferredFrom	[Reaction:R-HSA-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters - Homo sapiens
input	[SimpleEntity:R-ALL-113671] 2OG [nucleoplasm] [SimpleEntity:R-ALL-113685] O2 [nucleoplasm] [Complex:R-DRE-5625850] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters
output	[SimpleEntity:R-ALL-29478] CH2O [nucleoplasm] [SimpleEntity:R-ALL-159942] CO2 [nucleoplasm] [Complex:R-DRE-5625863] p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] [SimpleEntity:R-ALL-159939] SUCCA [nucleoplasm]
precedingEvent	[Reaction:R-DRE-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5625848
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
(precedingEvent)	[Reaction:R-DRE-5625870] KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters
(inferredTo)	[Reaction:R-HSA-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters

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