Reactome | RHO GTPases activate PKNs

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RHO GTPases activate PKNs Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10098709
displayName	RHO GTPases activate PKNs
eventOf	[Pathway:R-MMU-195258] RHO GTPase Effectors - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-5623622] RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 - Mus musculus [Reaction:R-MMU-5623632] RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 - Mus musculus [Reaction:R-MMU-5623667] PDPK1 phosphorylates PKN1,2,3 - Mus musculus [Pathway:R-MMU-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Mus musculus [Reaction:R-MMU-5671737] p-T774-PKN1 binds CDC25C - Mus musculus [Reaction:R-MMU-5671749] p-T774-PKN1 phosphorylates CDC25C - Mus musculus [Reaction:R-MMU-75016] Association of p-S216-CDC25C with 14-3-3 proteins - Mus musculus [Reaction:R-MMU-5671763] p-T774-PKN1 phosphorylates PPP1R14A - Mus musculus [Reaction:R-MMU-5671772] p-T38-PPP1R14A binds MLCP - Mus musculus
inferredFrom	[Pathway:R-HSA-5625740] RHO GTPases activate PKNs - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	RHO GTPases activate PKNs
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-5625740
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-195258] RHO GTPase Effectors
(hasEncapsulatedEvent)	[Pathway:R-MMU-8848021] Signaling by PTK6 [Pathway:R-MMU-5625900] RHO GTPases activate CIT [Pathway:R-MMU-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
(inferredTo)	[Pathway:R-HSA-5625740] RHO GTPases activate PKNs

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